The Syrian government has approved humanitarian access to seven besieged areas, the UN has said.
Convoys were being prepared to depart "as soon as possible", said spokesman Farhan Haq.
Among the areas due to receive aid is Madaya, where people have been dying of starvation.
World powers last week agreed to seek a nationwide "cessation of hostilities" and to accelerate and expand aid deliveries.
After talks in Damascus on Tuesday, the UN special envoy to Syria, Staffan de Mistura, said the Syrian government had a duty to allow access to whoever needed it.
This obligation, he said, would be put to the test on Wednesday.
The truce, which does not apply to jihadist groups, is due to come into force later this week.
But Syrian President Bashar al-Assad has cast doubts on the cessation, warning it would be "difficult" to implement and would not mean all parties would stop using weapons.
His forces, backed by Russian air power, have been advancing in the north and threaten to surround the key city of Aleppo.
Earlier Russia said it "categorically rejects" accusations of war crimes over the bombing of hospitals in Syria.
Turkey has blamed Russia for a series of rocket attacks on several hospitals and schools that killed up to 50 people.
But Kremlin spokesman Dmitry Peskov said that the only proof Russia would accept from the ground "comes from the Syrian authorities".
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