WORLD RESEARCH ARTICLE: HEALTH - Stem Cell Shortage Linked To Miscarriages

UK scientists are claiming a "breakthrough" into the cause of repeated miscarriages.

University of Warwick researchers say a lack of stem cells in the womb lining is the reason for recurrent loss of pregnancy.

One in five women experience a miscarriage, while about one in 100 suffer the loss of three or more consecutive pregnancies.
Researchers have been studying donated tissue samples in laboratories at the University Hospital of Coventry.

They claim the womb lining in recurrent miscarriage patients is "already defective" before pregnancy.

Scientists say they hope to correct these defects in the future before patients attempt other pregnancies.

Co-author of the research Professor Siobhan Quenby, from the University of Warwick, said the team will be working on new interventions.

"Every time you have your monthly cycle the stem cells actually move into the lining of the womb," he said.

"They come from the bone marrow, go into your blood and then go into the lining of the womb every month.

"As it's a constant renewing process that can be increased or decreased we are now going to work on ways to increase this renewing of stem cells in the lining of womb."

The team are about to start trialling new methods to improve womb lining including screening women at risk.

They will also explore the endometrial "scratch" procedure to try to help embryos implant.

In addition researchers will test a drug usually used to treat diabetes which has been known to stimulate stem cells.

Katy Gameson, from Warwickshire, suffered eight miscarriages over a year before giving birth to her second son, Hayden. She welcomes the research.

"Each one happened before six weeks," she told Sky News. "I just can't describe how hard it was. I just never thought we would have a little brother for our older son at that point.

"New breakthroughs are amazing. If there's something out there that can be done it needs to be done.

"There's so much heartache that could be avoided, you're silently suffering and it's hard."

A large miscarriage research centre will be launched at the University Hospital of Coventry with Warwick University scientists in April.

The centre, one of three in the UK, will be funded by the charity Tommy's.

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