A man and woman have died - and four children have been taken to hospital - after a fire at a house in Withington, Greater Manchester.
Details of the children's injuries - three girls and a boy, aged between 10 and 17 - are not known.
Another man was also taken to hospital and is said to be in a serious condition.
Firefighters, police and paramedics were called to the scene in Parsonage Road in the Ladybarn area at around 2.20am on Friday.
The man and woman killed in the blaze, died at the scene, said Greater Manchester Police.
A neighbour told the Manchester Evening News she was woken by screams and saw thick black smoke coming out of the house.
Firefighters spent several hours tackling the flames.
The fire appears to have been concentrated at the back of the semi-detached house, where a hole can be seen in the roof and a green tarpaulin covering a window.
A joint investigation has been launched by the police and fire service to determine the cause of the blaze.
Superintendent Mark Kenny described the blaze as "a tragic incident" and said: "I urge anyone who may have witnessed the fire, or anyone in the area in the hours before the fire.
"If you have any information at all contact police as soon as possible so we can piece together what happened."
Next of kin have been informed, but the bodies of the man and woman are yet to be formally identified.
Post-mortems are expected to take place in due course.
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