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Thursday, 15 August 2019

Medical/Health Research: Sperm separation technique could allow IVF gender selection

Scientists have developed a new sperm separation technique which could in future allow couples having IVF to choose if they have a boy or girl before fertilisation.



Experts in Japan report they have come up with a new method allowing them to split mouse sperm carrying an X chromosome from those carrying a Y chromosome.
It means sperm can be chosen based on whether they will result in female (XX) or male (XY) offspring when it is used to fertilise an egg.
It was thought the sperm of mammals that lead to both offspring are identical except for the DNA they carry.
But researchers at Hiroshima University found 492 genes are active in sperm that carry the X chromosome, which give rise to female offspring, that are not active in sperm that carry the Y chromosome, which lead to male offspring.
Some 18 of the X chromosome genes encoded receptors, and were good candidates for manipulating the sperm - because of their response to stimuli.
The team has found that a chemical that binds to two of these proteins can slow down the movement of X-carrying sperm without affecting the Y-carrying ones.

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